I don't know if this is a new bug but it is happening regularly to my Windows XP SP3 machine. I believe it only occurs when in full screen mode but I cannot confirm this 100%.
When I finish and close the game, after looking at the stats &c and then exit, I often find that the mouse/keyboard settings within Windows are all incorrect. Clicking on an icon on the windows desktop will cause the right click options to come up as if the mouse settings have been transposed. Also the keyboard appears to have been largely disabled/remapped as when I try to open an email or similar and type in the text area, nothing appears or perhaps some gibberish from certain keys.
It feels as if the virtual keyboard and mouse mapping from Coconet has somehow 'stuck'.